amazon-science/uniqsketch v1.5.0

v1.5.0 — uniqsketch --min-margin signature hardening

Repository: amazon-science/uniqsketch

Tag: v1.5.0

Published: 2026-07-17T17:37:48Z

Prerelease: no

Release notes:

Features

• `uniqsketch --min-margin=N`: harden signature selection against single-base sequencing errors.

With --min-margin=2, uniqsketch prefers signatures that lie at Hamming distance ≥ 2 from every k-mer in other references, so a single substitution error in a read cannot turn a foreign k-mer into one of a reference's signatures — a source of false-positive hits. It is a tiered preference: within each genomic selection slot a 2-safe, non-low-complexity candidate is chosen when available, falling back to the previous behavior only when a slot has no 2-safe option, so per-reference signature counts and genomic spacing are preserved. A summary line reports how many selected signatures met the margin. The default (--min-margin=1) leaves selection unchanged. Currently supports margins 1 and 2; higher margins are planned.

Full changelog: https://github.com/amazon-science/uniqsketch/blob/main/CHANGELOG.md