Strengthening societal resilience with Rosalind Biodefense

OpenAI

May 29, 2026

Product Research Release

Strengthening societal resilience with Rosalind Biodefense

Advancing biological preparedness with trusted developers and government partners.

Share

AI is accelerating progress across biology and the life sciences, creating new opportunities to advance scientific discovery, strengthen public health, and build resilience against biological threats. As these capabilities become more powerful, the institutions working to prevent, detect, and respond to biological threats need equally powerful tools. We believe frontier AI should meaningfully advantage those defenders—and that doing so requires responsible deployment structures and trusted access models that put advanced capabilities in the hands of vetted partners who are building new biodefense applications, tools and initiatives to bolster societal resilience.

That’s why today we’re announcing two new steps to advance defensive acceleration in biology:

• Launching Rosalind Biodefense to help trusted developers to build new biodefense and pandemic preparedness capabilities. Apply here.
• Expanding trusted access to GPT‑Rosalind for select U.S. government and allied partners supporting public health and biodefense missions. Request access here.

The steps we're taking today are part of a broader strategy to ensure advanced AI meaningfully advantages those working to prevent, detect, and respond to biological threats. That strategy includes equipping defenders through trusted access to advanced AI tools, accelerating the development of medical countermeasures, building earlier warning systems, strengthening diagnostics, preparedness, and response capabilities, and supporting a robust evaluations ecosystem. We will continue to share more about our work across these areas in the coming weeks.

Building on our safety and resilience work

As AI models become more capable in biology, we have been working to ensure those capabilities are deployed in ways that advance science while strengthening safeguards. Our approach has focused on building layered resilience: investing in preparedness evaluations, bio-specific capability assessments, safer model behavior for dual-use biological requests, monitoring and enforcement, expert red teaming, and security controls for higher-risk capabilities.

In July 2025, we released ChatGPT agent, the first model we treated as High Capability in biology under our Preparedness Framework and activated robust safeguards to minimize the risk of harm. Since then, we have continued refining those safeguards and sharing detailed assessments⁠(opens in a new window) as capabilities have continued to advance. We have also continued working closely with external testing groups on pre-deployment evaluations, whose findings help validate and inform our approach.

We have also worked closely with external experts and public-sector partners to strengthen the broader biosecurity ecosystem, including expert biologists, government organizations like the U.S. Center for AI Standards and Innovation (CAISI) and the UK AI Security Institute (UK AISI), Los Alamos National Laboratory, and the Frontier Model Forum. Today’s announcement builds on that work by expanding how trusted partners can use GPT‑Rosalind for high-impact defensive applications—both by supporting defenders building new countermeasures and by extending trusted access to government partners with public-health and biodefense missions.

• Request access

Supporting defensive acceleration with Rosalind Biodefense

Defensive acceleration focuses on making sure frontier AI capabilities meaningfully advantage the people building society’s defenses. To help trusted developers turn frontier capabilities into practical defenses, we are launching Rosalind Biodefense, a new initiative to enable the development of high-impact defensive applications of AI in the life sciences leveraging GPT‑Rosalind, our frontier reasoning model built for life sciences research.

This program helps trusted developers apply frontier AI capabilities to operationalized biodefense tools that can strengthen preparedness before the next biological threat emerges. OpenAI will sponsor access to GPT‑Rosalind and provide launch support to trusted developers building frontier biosecurity applications that can bolster societal defenses and build pandemic preparedness. This includes work across areas such as epidemiological modeling, early detection, screening, preparedness, non-pharmaceutical interventions (NPIs) and other public-health-relevant capabilities.

At launch, we are supporting a first set of organizations building frontier applications across the biological defense stack with GPT‑Rosalind. Their work spans the lifecycle of biological threats—from prevention and early detection to societal resilience and medical countermeasure development—and helps demonstrate how frontier AI can support public-health teams, researchers, infrastructure operators, and communities in preparing for future biological risks, whether naturally occurring or synthetic.

Fourth Eon Biosecurity builds adaptive screening infrastructure that can evolve alongside new technologies like AI. Starting with function-based screening for DNA synthesis, the organization helps labs and companies that handle biological materials prevent unsafe or malicious orders, including those involving novel designs.

> “We’re excited to test OpenAI’s GPT-Rosalind in Fourth Eon’s work developing AI-native biosecurity screening systems that analyze sequences and generate detailed threat assessments. Robust screening can improve the ability to detect and mitigate potentially dangerous DNA orders before they create downstream risk, strengthening prevention.”

– Gary Abel, Co-Founder & Chief Scientist

Our goal is not only to accelerate life sciences research in the abstract, but…